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SOLO Liquid Handler

Hudson Robotics equipment

Hudson SOLO™ - Flexible & Affordable Automated Liquid Handler

SOLO Liquid Handling pipetting robot

6-Position SOLO Pipettor. The SOLO is available with 4, 6, 8, 10, or 12 microplate positions.

The Hudson SOLO™ is a low cost, flexible and easy-to-use automated pipettor. Available in single, 8 and 12 channel pipette options the SOLO automated pipetting robot can be programmed to do anything expected of a hand-held pipettor, with greatly improved precision (see the Specifications tab):

  • The SOLO takes minutes to learn to use
  • Easy-to-use, agile and flexible software
  • As precise as any ‘big deck’ robotic liquid handling system

Simply set up the liquid handling steps in intuitive SOLOSoft control software and go. Equipped with a broad dynamic volume range and the ability to handle reactions in a sterile environment. It is about half the cost of other laboratory robotics platforms and has options of 4, 6, 8, 10, or 12 microplate nests on the deck.  The SOLO will fit into most biological safety cabinets, anaerobic chambers and fume hoods. The SOLO can be loaded and operated manually, but is also compatible with robotic arms from most manufacturers, including our PlateCrane EX. The small footprint and open design of the SOLO automated pipettor provide easy integration with accessories, such as heating and cooling nests, incubators, magnetic bead nests, automatable centrifuges, microplate readers and more. Our SoftLinx lab automation software has software Plug-ins to over 200 3rd party lab instruments. 

The SOLO liquid handler was developed to meet the growing need throughout the research, pharmaceutical and clinical communities for a high resolution compact robotic pipettor. The SOLO’s liquid handling provides researchers with walkaway freedom, a small footprint, and easy to use SOLOSoft software which is closely linked to our SoftLinx™ software for data tracking and scheduling, plus improved efficiency and decreased cost of continuous unattended operation systems.

The SOLO – multi-tip is available with either an 8-tip pipette head or 12-tip pipette head.  The SOLO is standard with a 6 position deck. No worries if you need to transfer samples quickly from plate to plate and then other times do a serial dilution across the plate.  The SOLO easily adapts without any tools to both heads. Use the 12-tip head to finish plate to plate transfers 50% faster than the 8-tip head, remove the head and add the 8 position head for easy serial dilutions.

Serial Dilution with the SOLO

Users who wish to cherry-pick from individual wells can use either the single-tip SOLO (as shown in the video clip below) or the multi-tip configuration.  The SOLO multi-tip (both 8-channel and 12-channel) can work with just 1 tip, several tips, or all the tips without any issues. There is no need to switch to a single tip pipette head. 

Cherry-Picking with the SOLO

The SOLO mutli-tip offers a broad pipetting range. The mechanical drive and software controls of the pipette head allow the SOLO to push the boundaries of pipetting performance. With CVs of less than 3% across the entire pipetting range users can save valuable time and expense by using a single pipette head for both multi-tip and single-tip operations. 

The SOLO automated pipettors provide many benefits to the lab:

  • Single-, 8- & 12-channel pipetting heads are available.
  • The 8- & 12-channel SOLO instruments can use only 1 tip without compromising performance saving valuable time and expense.
  • The SOLO offers many pipetting option to give the SOLO user the ability to dispense accurate  volumes (from 500nL to 10ml) with CVs better than 3%.
  • The SOLO offers email functionality in the software that alerts the user when a run is completed or that an error has occurred.
  • The SOLO can easily be integrated with additional instruments and software at anytime.
  • The SOLO is easily customized for unique or specialized applications.

Click here to download the SOLO automated Pipettor brochure.


The SOLO is the ideal automated pipetting robot for a wide variety of applications. The SOLO offers the fully developed applications including:
  • Serial Dilutions
  • Next Gen Sequencing (NGS)
  • Gene assembly
  • DNA extraction
  • DNA Normalization
  • ELISAs
  • Serial Dilutions
  • Hit Picking
  • Kinase Assays
For a full list of applications please click here.

PlateCrane EX Robot Arm

  • Easy integration using SoftLinx
  • Up to 15 stacks, 450 plate capacity
  • Easy combination with SOLOSoft methods
  • Access to any SOLO plate nest
PlateCrane SciClops Laboratory automation, Microplate Handler
LabLinx Microplate Stacker

  • Feeds plates on track mounted directly to SOLO deck
  • Up to 4 Stackers per SOLO, 480 microplate capacity
  • Easy integration using SoftLinx
  • Multiple plates handled simultaneously
  • Easy combination with SOLOSoft methods
  • Access to any SOLO plate nest
Micro10x Reagent Dispenser

  • Fast, accurate dispensing of bulk reagents
  • 8- or 12-channel dispense manifolds
  • Portrait or Landscape orientation
  • Mounts to SOLO as a plate nest position
  • Easily integrates into SOLOSoft pipetting methods
  • Dramatically increases SOLO throughput
FilterPress Pressure Filtration Station

  • Dispense samples and solvents directly into filter plates
  • Computer control of pressure ramp-up/down
  • Detects and reports actual pressure level
  • Easy integration using SoftLinx
  • Mounts to SOLO as a plate nest position
Heating/Cooling Nest

  • Electrical: 100 – 260 VAC; 50-60 Hz; 0.5W
  • RS-232 interface through SOLOSoft
  • Temp. Range: -10°C to 100°C
  • Logs actual nest temperature during run
  • Easy integration into SOLOSoft pipetting methods
  • Flexible user options:
Shaker Nest

  • Electrical: 115 – 230 VAC; 50-60 Hz; 3W
  • RS-232 interface through SOLOSoft
  • Shaking Speed: 100 to 2000RPM
  • Up to 4 independently-controlled shaker nests per SOLO
  • Easy integration into SOLOSoft pipetting methods
  • Control of Shake Speed, Shake Time, Acceleration and Shaking Pattern:

The SOLO was developed to meet the growing need throughout the research, pharmaceutical and clinical communities for a high resolution compact robotic pipettor. It can be adapted to any research activity which requires the accurate addition, removal and mixing of liquid samples and reagents – including those containing live cells.  The SOLO can be integrated with other automated instruments for seamless process control and flexibility and has many uses in applications involving:

DNA Extraction

DNA Extraction

DNA/RNA/Protein Extraction – Isolate pure DNA from the cell.  There are a wide variety of protocols available for isolating pure DNA from all sorts of material.  But they all involve the same four basic steps: lysis, adsorption, washing and elution.  The details vary, depending on the source material and the concentration of DNA expected.

Microbiome/Microbiota Research

Microbiome/Microbiota Research

Hudson Robotics can help researchers that are studying the microbiota (gut microbiome) in anaerobic chambers with its small form factor, automated tools for bacterial colony-picking, sample preparation, DNA extraction, plasmid preparation and DNA normalization. Research on Gastrointestinal disorders, Infectious diseases, metabolic disorders, immunology, oncology and CNS are all possible using Hudson technologies.

Oligo Pooling

Oligo Pooling

Hudson offers an automated solution for pooling of oligos.  Following the downloaded sequence instructions,  SoftLinx directs the system’s pipettor to pool the appropriate oligos to enable the final assembly process to achieve the full gene sequence desired.

Gene Assembly

Gene Assembly

Hudson has succeeded in automating the gene assembly process, the key first step of a typical synthetic biology pipeline.  We have gene assembly solutions that can be integrated with commercial automated oligo synthesizers, as well as subsequent de-protection and purification.  In addition, we can pool oligos and carry them through the complete process to form functioning genes and complete genomes, such as viruses.

DNA and RNA Normalization

DNA and RNA Normalization

Utilizing the simplicity of Hudson’s SOLO, and SoftLinx Software, users perform accurate DNA normalization of any plate of DNA samples.  Using the SOLO to perform all the solvent addition, mixing and sample transfer operations, the user selects a DNA quantification file, and starts the system.

Synthetic Biology

Synthetic Biology

Hudson Robotics’ unique capabilities and product mix have enabled us to lead the entire world in the automation of the complete Synthetic Biology Pipeline:  from automated oligo synthesis and gene assembly through transformation, colony picking and plasmid preparation.

Combined with our previous work with protein expression and purification systems, Hudson now offers a solution to automating any process encountered in a typical molecular biology laboratory.  

Plasmid Preparation

Plasmid Preparation

Obtaining pure DNA plasmids from bacteria are frequently carried out by lysing the cells and separating the plasmids through filter columns.  Hudson offers a fully automated solution to this application. Plasmid purification is a technique used to isolate and purify plasmid DNA from genomic DNA, proteins, ribosomes, and the bacterial cell wall. A plasmid is a small, circular, double-stranded DNA that is used as a carrier of specific DNA molecules. When introduced into a host organism via transformation, a plasmid will be replicated, creating numerous copies of the DNA fragment under study.

Fungal, Yeast, Stem Cell, Bacterial Colony Picking

Fungal, Yeast, Stem Cell, Bacterial Colony Picking

Hudson has been a key player in the colony picking arena for many years.  We offer several versions of our RapidPick platform, including the recently introduced single-pin picker.  Easy-to-use, but sophisticated software interacts with the picker and the incorporated camera to identify and select appropriate colonies.

Colony Plating

Colony Plating

Colony plating is a key process in various applications that require the replication and distribution of viable cell cultures.  It can also be used to determine if a transformation procedure was successful in introducing an observable property upon a culture, such as the common process of introducing ampicillin resistance.

DNA Transformation into Bacteria

DNA Transformation into Bacteria

Transformation, in which DNA is incorporated into a bacterial cell, is a key step in many biological and pharmaceutical applications.  Hudson has developed a number of automated systems for transforming cells by the heat shock approach.

Protein Binding

Protein Binding

“Equilibrium dialysis is the gold standard for determining the fraction of test compounds bound to serum/plasma or microsomal proteins.  The equilibrium dialysis approach allows the determination of ligand/compound binding to the entire spectrum of biological proteins as well as tissue binding distribution while minimizing experimental artifacts.

Protein Expression & Purification

Protein Expression & Purification

Hudson offers a wide range of instrumentation to support the entire range of protocols commonly encountered when preparing peptides and proteins.  From liquid handlers to support PCR through vast, multi-component systems to support an entire research effort.

Handling Non-Standard Sample Plates

Handling Non-Standard Sample Plates

Hudson’s PlateCrane and LabLinx are industry standard instruments for moving SBS-standard microplate around multi-component workcells.  However, another best-kept secret about Hudson is our array of accessories that allow users to manipulate all kinds of non-standard “plates”; including microscope slides and …



ELISA (enzyme-linked immunosorbent assays) represent one of the most heavily used tests in biological research. Our systems support many variants, such as the standard “sandwich” ELISA.  Our systems can be easily customized to support any non-standard process.

Serial Dilutions

Serial Dilutions

A key step to quantify concentration-dependent affects.  A step-wise dilution of a sample through a series of pipette aspirations/dispenses.  Automating this process is essential to maximize the accuracy of the resulting data.

The SOLO easily fits on lab benchtops and into standard fume hoods and biosafety cabinets. It can automate large and small volume experiments, is adaptable to common well plate formats and can improve the quality and reliability of research. The SOLO can work as an unattended stand alone instrument which can save time and decrease cost and users can learn to use Hudson’s Softlinx software in just minutes. The product also can preserve sterility and avoid cross-contamination while dispensing into slides and microplates.  The SOLO high-throughput single-channel pipettor has features researchers will find very desirable in a benchtop instrument including:

  • Compact as small as 14″ x 16″ (355mm x 400mm) footprint for a 4 microplate position SOLO
  • 8-, 24-, 96-, 384- and 1536-well microplate compatible
  • Compatible with a wide variety of non-standard vials, test tubes and reagent reservoirs
  • Broad volume range: 500nl to 1000ul for the multi-tip heads, 500nL to 10mL for the single-tip heads.
  • Easily fits in a standard hood
  • Fully compatible with robot loading systems or can be used manually as a stand alone unit
  • Plate stacker upgrade available anytime for unparalleled flexibility and high throughput
  • Easy to use SOLOSoft control software for simple programming of pipetting steps
  • Includes Hudson Robotics’ SoftLinx software, which provides an easy-to-use interface to coordinate the SOLO’s operation with other automated instruments

Dispensing : Single channel – 1ul to 10 ml; optional pump assembly for bulk dispensing
8 & 12 channel : 1-10 ul pipette head; 5 – 200ul pipette head; 20 – 1000 ul pipette head

Plate Capacity
: 4, 6, 8, 10,12 microplate positions available

Optional Microplate Gripper : Move plates to accessories on the deck or other instruments

Plate Format : SBS standard footprint, any well configuration; inquire about custom nests

Tubes, Flasks and Vials: Any format

Housing material : Stainless main deck; painted steel upper arm covers over machined aluminum structural components

Spill Protection : All electronics protected by solid, non-penetrated cover to prevent any leakage onto electrical devices

Arm Mechanism: Horizontal Travel/Vertical Stroke: x=22.5″; y=9.3″; z=4.0″

Size : As small as 24.0″ x 29.5″ x 19.5″ (H x W x D)  for a 4 microplate position SOLO

Weight : 50lbs

Power Requirements:  120-240 VAC, 50-60Hz, 2Amps Max at 120

Computer Interface : RS-232 serial cable

Precision:  The high-resolution motor that drives the SOLO’s pipette greatly increases it’s precision.  Results vary depending on the nature of the liquid and the exact method of aspiration and dispense, but in general, a pipette rated at 20-200uL will dispense as low as 2uL with an average CV below 2%.  Larger volumes are dispensed with CVs under 0.5%. 

Equipping the SOLO with a lower volume pipette allows one to dispense liquids in the nanomolar range with similar precision.  Click here to view a recent white paper that discusses pipetting techniques and their effect on precision.

Speed: Below are some timing results based on filling each well of a 96 well plate with 5uL of liquid, one well at a time.


Average Time/ Plate (min:sec)

Aspirate from a reservoir (Same point each time)


Copy plate – well by well with no tip changes


Copy plate – well by well with 96 tip changes


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