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Protein BindingProtein Binding

Equilibrium dialysis stands as the gold standard for determining the fraction of test compounds bound to serum/plasma or microsomal proteins, offering unparalleled accuracy in drug discovery and pharmacokinetic studies. Hudson Robotics integrates the HTD96b from HTDialysis with its SOLO pipettor, automating a diverse range of applications such as tissue binding, drug partitioning, receptor binding, and more.

Key Advantages:

  1. Comprehensive Protein Binding Analysis: The equilibrium dialysis approach enables the determination of ligand/compound binding to a wide spectrum of biological proteins and tissue binding distribution, minimizing experimental artifacts and ensuring robust results.
  2. Proven Performance: Trusted by leading pharmaceutical, biotechnology companies, academic laboratories, and contract research organizations worldwide since 2003, the HTD96b offers reliability and consistency in protein binding studies.
  3. Optimized Design: Featuring 100% Teflon construction, the HTD96b minimizes non-specific binding to the dialysis apparatus, accelerating equilibrium attainment and reducing assay time. Additionally, its reusable design and low operational cost make it the most cost-effective high-throughput equilibrium dialysis apparatus available on the market.
  4. Versatile Membrane Compatibility: The HTD96b accommodates regenerated cellulose membranes with a wide range of molecular pore sizes (3.5KDa, 6-8KDa, 10KDa, 12-14KDa, 25KDa, and 50KDa), catering to diverse experimental needs and ensuring flexibility in protein binding studies.

The HTD96b on the deck of the SOLO below:

ht dialysis protein binding


In the following video, the SOLO distributes serum samples and buffer to each half of the wells of the HTD96b from HTDialysis