Digital-to-biological converter for on demand production of biologics

Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization. The authors report the development of a digital-to-biological converter for fully automated, versatile and demand-based production of functional biologics starting from DNA sequence information. Specifically, DNA templates, RNA molecules, proteins and viral particles were produced in an automated fashion from digitally transmitted DNA sequences without human intervention.

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What if a solution could be found that would produce accurate, variable dilutions across an entire plate in less than 1 minute per target plate?

The field of plasmid-based functional proteomics requires the rapid assay of proteins expressed from plasmid libraries. Automation is essential since large sets of mutant open reading frames are being cloned for evaluation. To date no integrated automated platform is available to carry out the entire process including production of plasmid libraries, expression of cloned genes, and functional testing of expressed proteins.

Recent software advancements have made it much easier to automate almost any procedure typically carried out in a drug discovery laboratory. It is now possible to design “virtual workcells” from a small, dedicated collection of liquid and microplate handling robots to carry out the simplest or most complicated procedures.