Transformation, in which DNA is incorporated into a bacterial cell, is a key step in many biological and pharmaceutical applications. Modified DNA can change the phenotypic characteristics of an organism, such as thermal stability, or it can be used to turn a bacteria into a drug-producing factory. The process requires cells that can pass DNA through their cell wall, ie. competent cells. Currently, the two general approaches to transform cells are heat-shock and electroporation. Hudson has developed a number of automated systems that transform Bacterial cells using heat shock-based protocols.
Transformation is a key part of the following Applications Pipelines that we support: