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Tomtec Quadra4 Liquid Handling Workstation

Overview
Description
Specifications
Applications
Docs & Videos
Accessories

An intuitive pipetting system with six stations supports a range of accessories for automated sample prep like SPE, magnetic bead cleanup, dilutions and standards additions.

The Quadra4 liquid handling workstation can be configured for a number of tasks. Including automated SPE – both positive and negative pressure, accurate sample transfers, precise standards additions, sample dilutions, and magnetic bead cleanup. When changing methods, no recalibration is required with Tomtec’s fixed 24, 96, or 384 tip pipetting heads, making Quadra4 simpler to operate than systems five-times its price. The Quadra4’s software, with optional 21CFR11 toolkit, enables use in both non-regulated and regulated environments. Optional automated plate stackers provide true walk-away high-throughput plate prep.
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Tomtec Quadra4 Liquid Handling Workstation
Tomtec Quadra4 Liquid Handling Workstation
Tomtec Quadra4 Liquid Handling Workstation
Tomtec Quadra4 Liquid Handler
Tomtec Quadra Liquid Handler

Description

With over 40 years of experience in automated liquid handling, the Tomtec Quadra4 Liquid Handling Workstation sets the standard for a cost effective liquid handling workstation for life science applications. The workstation is engineered around a reliable fixed-head air displacement syringe design which services a six-station shuttle. The six stations can support a wide range of accessories for automating sample preparation like solid phase extraction (SPE), magnetic bead cleanup, as well as dilutions and standards additions. With an optional plate-stacker, the Quadra4 can be used to queue up to 50 assays. With an easy to learn, user friendly WIN 10 64 bit graphical interface, the Quadra4 delivers speed, flexibility, and precision.

Each Quadra4 Liquid Handling Workstation is manufactured in our Connecticut and New Jersey facilities. Tomtec engineers work with your research team to understand your analytical sample requirements, and then recommend the best possible solutions at the best possible price. When the Quadra4 Liquid Handling Workstation is delivered to your laboratory, Tomtec engineers install and test your system and familiarize your team on how to get the most value from your Tomtec investment. With both air displacement pipetting, in conjunction with an optional indexing microplate stage, the Quadra4 Liquid Handling Workstation enables the support of complex pipette workloads found on workstations that cost five-times its price. In addition, the optional automated plate stacker’s provide true walk-away assay automation.

The Quadra4 provides:

  • Highly precise and consistent, accurate pipetting for 24, 96, 384 ANSI microplates.
  • Wide spectrum flow rate with the sensitivity and utility to handle a wide range of aqueous and organic solutions within the same workflow.
  • Process logs for assay validation and QC with full barcode support and LIMS integration.
  • Intuitive and flexible Graphical User Interface (GUI) for set-up and monitoring workflows

Specifications

Bioanalytical Applications General Capabilities Precise Assay Automation
450ul tips with a cannula to access deep well plates Flexibility to support 96 well pipetting with either 450ul, 250ul, 50ul, or 20ul clear plastic tips Precision 96 well positive displacement pipetting at 60ul to 0.5ul @ ± 2.5%
Aqueous, to organic, to aqueous, without a tip change Automated serial dilution with either 8 or 12 tips Precision 384 well positive displacement pipetting at 60ul to 0.5ul@ ± 2.5%
Manual or automated vacuum box options Pipette multiple reagents, within the same tip, using air gap separation to accelerate work-flows Automated 96 to 384 to 1536 reformatting
Stacker in-feed/out-feed for microplates and reservoirs provides walk away automation Non contact dispensing
Six station shuttle to support multiple microplates and reservoirs Pipetting heads configured for 24 to 96 to 384 and/or 1536 well assays as well as specialized heads.
SPE Liquid/Liquid extraction, optional positive pressure SPE Cost effective Non sterilized and sterilized pipette available directly from Tomtec
Ultrasonic tip washing and magnetic bead toolsets available

Applications

Sample preparation for qualitative and quantitative LCMSMS

Sample preparation and transfer from 24 vials formats to microtiter plates formats

24 and 96 tip pipetting heads are ideal for blood/fecal samples in vials for prep for GC MS, then transfer to 96 well plates for LCMSMS

High Thoughput Screening for NME

Solid Phase Extraction

Sandwich ELISA

Genomics – Sample Preparation and PCR

Drug Testing (metabolites -NIDA-5)

Documents & Videos

Quadra4 Liquid Handling Workstation Product Bulletin

Accessories

120686
Contaminated Tip Removal Assembly
320-30
96/384 Plate / Reservoir Nest, Standard Version 1-1/2” High (Used on Quadra 3/4 )
320-31
1536 Plate Nest (Used on Quadra 3/4)
320-34
96/384 Plate Reservoir Nest, Short Version 1” High (Used on Quadra 3/4)
320-40
384 PCR Plate Nest (Used on Quadra 3/4)
320-50
Tip Loading Fixture , 96 Well 450ul Head (Used on Quadra 3/4)
320-51
Tip Loading Fixture , 384 & 96 Well 55ul SV Head (Used on Quadra 3/4)
320-52
Tip Loading Fixture (Used on Pipetting Head Tip & Seal Power Wash System)
320-53
Tip Loading Fixture , 96 Well 20ul DSV Head (Used on Quadra 3/4)
330-10
BarCode Reader with Installation Kit. Used on Quadra 3 & Quadra 4 (4000 Series ONLY) 4100 Series – See 410-10
340-35
Teflon Coated Aluminum Reservoir
4000-730
Quadra 4 Command System Software (MS Windows)
890-710-12
Keyboard with Trackball, USB, Wireless (Used on Quadra 4)
OM4000
Quadra 4 Operator’s Manual
120322-02
Touch-Off Stage Assemblyy (Quadra 4 SPE/LTD – 4000 Series)
120322-03
Touch-Off Stage Assembly (Quadra 4SPE or LTD – 4100 Series)
196-503
SPE Vacuum Box w/ Control ModuleIncludes: 020484 & 330-59
410-10
BarCode Reader with Installation Kit. Used on Quadra 4 (4100 Series ONLY)
20484
SPE Vacuum Box Control Module ONLY
027107-01
PCR Tube Support Plate (Used on Quadra 3 / 4)
120329-01
Shaker Nest Auxiliary Power KitIncludes: Power Supply, Adapter, & Line Cord(Used with 320-75, 320-75J, 520-75, 520-75J Shaker Nest)NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
120955-02
Mirror Rack Nest Assembly (New Style), Quadra 4
120973-01
8 Tip Transfer Tool (Required when doing Serial Dilutions)
196-506
Thermal Retention Reservoir (Used with Disposable Reservoirs)
300-52
Pipetting Head Alignment Fixture
300-60
Pipetting Head Tip & Seal Power Wash / Back Flush SystemIncludes: 300-61 and 300-62NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
300-61
Pipetting Head Tip & Seal Power Wash System ONLY
300-730-04
Quadra 3 Command System Software – CD ONLY (Version 4.2.1. And Higher)
320-11
Low Volume Serpentine Reservoir, White Teflon(Use with 384SV Pipetting Head)
320-32
384 Tip Alignment Block for 384 & 1536 Pipetting (Quadra 3/4 & Quadra Plus)
320-33
96 Tip Alignment Block for 384 & 1536 Pipetting (Quadra 3/4 & Quadra Plus)
320-384
Low Volume Serpentine Reservoir, White Delrin(Use with 384SV Pipetting Head)
320-54
Tip Adapter Plate, Set of 5 (96 Well 20ul DSV Pipetting Head) Used with Quadra 3/4
320-55
Plate Spacer, Set of 5 (96 Well 20ul DSV Pipetting Head) Used with Quadra 3/4
320-70
Magnetic Nest – 96 Well, POST Design with Standard Magnet Configuration(Used with Quadra 3/4)
320-70A
Magnetic Nest – 384 Well PCR Plates (Used with Quadra 3/4)
320-75
Shaker Nest Assembly (Used with Quadra 3/4)Note: If Unit is Used Off-Line, P/N 120329-01 (-02, etc.) Shaker Nest Auxiliary Power Kit isRequired
320-96
Low Volume Serpentine Reservoir, White Delrin(Use with 96SV Pipetting Head)
330-54
Semi-Automated Filtration System Includes: 330-58 MANUALLY REGULATED MINI VACUUM TRAP and 330-59 SPE Vacuum Box(Used with Quadra 3 SPE/4 SPE)
330-56
AutoHand Option – Integrated Robotic Hand Only – (Factory installed)Used with Quadra 3/4
330-57
Automated Vacuum Box (Used with Quadra 3/4)
330-58
MANUALLY REGULATED MINI VACUUM TRAP(Used with Quadra 3 SPE/Q4 SPE & 330-54 Semi-Automated Filtration System.)
330-59
SPE Vacuum Box Option (No Control Module) Used with Quadra 3 SPE/4 SPE and as Vacuum Box Assembly Replacement)
330-95
Quadra AC Interface Control SystemIncludes: Control Unit, Line Cord, Communication Cable, & FuseUsed with Q96, Q3 ,& Q-Plus to allow switching of up to (2) AC Accessories thru QuadraProgramming.NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
340-21
Heated Nest, Round Bottom (115-230VAC/50-60HZ) Quadra 3/4(Used with Round Bottom Microtiter Plates)NOTE: Requires 340-20 Control Module
340-22
Heat/Chill Nest (Peltier) (115-230VAC/50-60HZ) Quadra 3/4(Used with Reservoirs or Flat Bottom Microtiter Plates)NOTE: Requires 340-20 Control Module
4340-50
PSID -2 ( Positive Sample Identification Module ) – (100-115VAC – 50/60Hz)
828-001-10
Null-Modem Cable, DB9 Female to DB9 Female, 10 ‘ Long(Quadra 3 Communication Cable)
300-62
24VDC Standalone Autotrap System ONLYIncludes: Autotrap, Power Supply, Line Cord, & Accessories)(Replaces: 96-10, 96-11, 96-19) (Used with 300-60 Powerwash & Backflush System)NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
020689-01
Peristaltic Pump, Dual HeadUsed with all Tip Washing Systems, Autogizers, & Recirculating ReservoirsNOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
120281
Stacker Cassette Assembly – 25 Plate CapacityIncludes: (1) 020448 Cassette Assy and (1) 020807 Follower Plate Assy(Used with Quadra 3/4, Quadra Plus, Quadra Wash II, and Autosealer)
120282
Dual Cassette Assembly – Increases Stacker Capacity to 50 PlatesIncludes: (1) 020448 Casette Assembly and (1) 020923 Adapter Assembly
121056-31
Ultrasonic Tip Washing Control Module and Bath (w/Umbilical & Line Cord) – ONLY (MATCHEDSET) – Used with Quadra 3/4NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
121056-41
Ultrasonic Tip Washing Control Module and Bath (w/Umbilical & Line Cord) – ONLY – (MATCHEDSET) – DMSO RESISTANT (Polypropylene Bath Body, Tygon Tubing in Umbilical) – Used withQuadra 3/4NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
196-135-31
Constant Level Recirculating Reservoir SystemIncludes: Reservoir, Peristaltic Pump, and Tubing KitUse with Quadra 3/4NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
196-370-31
Live Bottom Continuous Flow Reservoir SystemIncludes: Continuous Flow Reservoir and Peristaltic Pump (Used with Quadra 3/4)NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
196-460-31
Ultrasonic Tip Washing System – Includes: 121056-31 Control Module & Bath Assy, PeristalticPump w/Tubing, & Accessory Kit – Used with Quadra 3/4NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
196-460-41
Ultrasonic Tip Washing System – DMSO RESISTANT Includes: 121056-41 Control Module & BathAssy, Peristaltic Pump w/Tubing, & Accessory Kit – (Polypropylene Bath Body, Tygon Tubing inUmbilical) Used with Quadra 3/4NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
320-10
Low Volume Serpentine Reservoir, White Teflon(Use with 96SV Pipetting Head)
330-23
Tip Rack Press Assy (Tip Feeder)(Quadra 3 /4)
340-20
Control Module, Heat & Heat/Chill Nest(Used with 340-21, 340-22, 340-24, 540-21, 540-22, & 540-24 Heat/Chill Nest Assemblies)NOTE: PURCHASE ORDER MUST INDICATE REQUIRED VOLTAGE & FREQUENCY
340-24
Heated Nest, Flat Bottom (115-230VAC/50-60HZ) Quadra 3/4(Used with Reservoirs or Flat Bottom Microtiter Plates )NOTE: Requires 340-20 Control Module
4000-470
21 CFR Part 11 – Data Security, Digital Signature & Audit Trail Module(Requires 4000-730 Quadra Command Software Version)
4000-64-01
Regulated Postive Pressure Option (Factory Install)Use with Quadra 4SPE or 4NS “SPE”w/ 330-58 or 430-65 Mini Vacuum TrapInstallation Includes: SPE Pressure Block Assembly w/ Fixture, Electronic Pressure Regulator,Side Cover, Tubing, and Hardware. NOTE: MINI VACUUM TRAP NOT INCLUDED
4000-64-02
Regulated Postive Pressure Option (Factory Install)Use with Quadra 4 ONLYw/ 330-58 or 430-65 Mini Vacuum TrapInstallation Includes: SPE Pressure Block Assembly w/ Fixture, Electronic Pressure Regulator,Side Cover, Tubing and Hardware. NOTE: MINI VACUUM TRAP NOT INCLUDED
430-54
Automated Filtration System. Includes: 430-65 AUTO REGULATED MINI VACUUM TRAP and 330-59 Vacuum Box(Used with Quadra 4SPE & Quadra $NS “SPE”)
430-55
Fully Automated Filtration System (Factory Install)Includes: 330-56 AutoHand, 330-57 Autovac Box, &430-65 Auto Regulated Mini Vacuum TrapUsed with Quadra 4
430-65
AUTO REGULATED MINI VACUUM TRAP(Used with Quadra 4SPE, Quadra 4NS “SPE” and 430-54 Automated Filtration System)
IQOQPQ 4100
Quality Performance Procedure (Quadra 4 – Model 4100-10)
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