The RapidHit application software enables the user to establish the appropriate “hit” selection criteria, select the location on the network of the plate reader’s output files, the database where the assay plates are linked to the compound plate IDs, and the desired location of the RapidHit‘s own compound-to-hit well log files. When the RapidHit is running, the user can monitor the hits being selected even while the pipettor is making the transfers.
While an actual hit-picking run is in progress, this display allows the user to monitor the actual reader data for each well in the primary screen assay plate, as well as see the barcode ID of that Assay Plate, its associated Compound Plate, and the current hit-pick Target Plate that is being filled by the pipettor, which will contain the hits themselves. An example of this display, for a 384-well plate, is shown below:
Running in background behind the RapidHit application display is Hudson’s powerful automated workcell scheduler software, SoftLinx. SoftLinx coordinates the operation of the pipettor, the stackers and the barcode scanners to run the RapidHit application seamlessly with the user’s primary screening application.
Also running in background is Hudson’s SoloSoft software, which operates the pipettor and organizes the pipettor’s hit-picking operation.