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Transformation

Hudson Robotics equipment

Transformation

Transformation, in which DNA is incorporated into a bacterial cell, is a key step in many biological and pharmaceutical applications.  Modified DNA can change the phenotypic characteristics of an organism, such as thermal stability, or it can be used to turn a bacteria into a drug-producing factory.  The process requires cells that can pass DNA through their cell wall, ie. competent cells.  Currently, the two general approaches to transform cells are heat-shock and electroporation.  Hudson has developed a number of automated systems that transform cells using heat shock-based protocols.

Synthetic Biology Pipeline


Transformation is a key part of the following Applications Pipelines that we support:

SOLO Liquid Handler

SOLO Liquid Handler

The Hudson SOLO™ liquid handling robot is an automated pipettor that can do anything expected of a hand-held pipettor perfectly, at about half the cost of other laboratory robotics platforms, without human error. The Solo works well below 1ul (1-3ul CV=1%; 0.25ul CV=4%). The Solo will fit into most biological safety cabinets and fume hoods. The SOLO can be loaded and operated manually, but is also compatible with robot loading systems from most manufacturers, including our PlateCrane EX.

Automated Bacterial Transformation and Plating using the Hudson Solo Pipettor

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