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Serial Dilutions

Hudson Robotics equipment

Serial Dilutions

Serial_Dilution_PlateSerial dilutions are one of the most commonly used applications in the lab. The user pipettes a concentrated sample into a desired location and fills a series of additional locations with a fixed amount of diluent.  A fixed amount of the concentrated sample is aspirated and mixed with the first location containing diluent.  The same amount of this mixture is then aspirated and mixed with the next location containing diluent.  This procedure is continued until a range of decreasing concentration of sample is produced.  The number of samples that are handled per step depends on the number of available pipette channels.  The rate of decrease in concentration through the series depends on the relative amount of sample aspirated compared to the amount of diluent in the next location.  The most common case, a 2X serial dilution, is the case in which both volumes are the same.

Lab Automation is perfectly suited for simplifying serial dilutions, and at the same time assuring maximum accuracy.  A multi-channel SOLO Automated pipettor can carry out serial dilutions of 8 or 12 samples at a time, depending on the number of channels being employed.  Combining SOLO automated pipettor with the Micro10x reagent dispenser which can greatly increase the speed of diluent addition.

SOLO Liquid Handler

SOLO Liquid Handler

The Hudson SOLO™ liquid handling robot is an automated pipettor that can do anything expected of a hand-held pipettor, perfectly. It is about half the cost of other laboratory robotics platforms and has options of 4, 6, 8, 10, or 12 microplate nests on the deck.  The SOLO will fit into most biological safety cabinets, anaerobic chambers and fume hoods. The SOLO can be loaded and operated manually, but is also compatible with robotic arms from most manufacturers, including our PlateCrane EX. The small footprint and open design of the SOLO automated pipettor provides easy integration with accessories, such as heating and cooling nests, incubators, magnetic bead nests, automatable centrifuges, microplate readers and more. Our SoftLinx lab automation software has software Plug-ins to over 200 3rd party lab instruments. 

WellPro (Serial Dilution)

WellPro (Serial Dilution)

Hudson has developed a SoftLinx interface which allows one to automate the serial dilution of a wide range of plates using the ProGroup’s WellPro….

DNA Extraction Systems (DNA, RNA and Proteins)

DNA Extraction Systems (DNA, RNA and Proteins)

Hudson Robotics has introduced DNA extraction designs  to enhance our expanding catalog of powerful systems to support genetic research efforts.  Our DNA extraction system greatly simplifies the process of isolating pure nucleic acids and/or proteins from a wide variety of natural sources.

Promega GloMax® Integration

Promega GloMax® Integration

Our plug-in supports the new Promega GloMax® multi-mode reader.  We’ve used this integration as part of automating several of Promega’s luminescence-based assays, as well as various absorbance and fluorescence-based protocols.

In the following video, the SOLO handles the individual samples and the Micro10x distributes the diluant

In this video, the SOLO carries out the entire serial dilution

In the following video, a single-channel SOLO pipettor carries out a serial dilution in 1.5mL Matrix tubes.

For those labs that perform serial dilutions with the WellPro, we offer an integration package that automatically feeds and stores samples with our PlateCrane

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